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ثبت ژن HMGR از فندق ایرانی

1393/01/20 | توسط مدیریت
گروه بيوتكنولوژي پژوهشكده گياهان دارويي جهاددانشگاهي موفق به ثبت ژن HMGR از فندق ایرانی (Voucher: 705IMPH) در پایگاه اطلاعات بیوانفورماتیک NCBI شد.

گروه بيوتكنولوژي پژوهشكده گياهان دارويي جهاددانشگاهي موفق به ثبت ژن HMGR از فندق ایرانی (Voucher: 705IMPH) در پایگاه اطلاعات بیوانفورماتیک NCBI شد.

 

- جداسازی، همسانه‌سازی و ثبت ژن HMGR از فندق ایرانی (Voucher: 705IMPH) در پایگاه اطلاعات بیوانفورماتیک NCBI

به گزارش روابط عمومي پژوهشكده گياهان دارويي جهاددانشگاهي این ژن که کد کننده آنزیم کلیدی

3-hydroxy-3-methylglutaryl-CoA reductase  در مسیر بیوسنتزی موالونات است. نقشی تعیین کننده در تولید ایزوپرنوئیدهایی نظیر تاکسول در گیاهان دارد. بیان این ژن توسط سیگنال­های متفاوت توسعه‌ای ومحیطی مانند: نور، زخم، آلودگی، هورمون ها، علف‌کش‌ها و استرول‌ها تنظیم می­گردد. ژن جدا شده از درخت فندق ایرانی (Gene bank accession number KF306244) دارای طولی برابر با 1698 جفت باز است که کد کننده یک توالی 566 اسید آمینه­ای است. همچنین در تحقیقات تکمیلی نشان داده شد که افزایش بیان و راندمان ترجمه این ژن میزان تولید متابولیت تاکسول تا سه برابر افزایش داده است.

 
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